# Publications — Andrechek Lab

- [Insights from Genomic Sequencing of Preclinical Breast Cancer Models Establish Human Parallels to Increase Therapeutic Applicability.](https://pubmed.ncbi.nlm.nih.gov/41649611/) — Schulte AJ, Andrechek ER. J Mammary Gland Biol Neoplasia. 2026 Feb 6;31(1). doi: 10.1007/s10911-026-09599-7. PMID: 41649611.
- [Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model.](https://pubmed.ncbi.nlm.nih.gov/39341991/) — To B, Broeker C, Jhan JR, Garcia-Lerena J, Vusich J, Rempel R, Rennhack JP, Hollern D, Jackson L, Judah D, Swiatnicki M, Bylett E, Kubiak R, Honeysett J, Nevins J, Andrechek E. Oncogene. 2024 Nov;43(46):3402-3415. doi: 10.1038/s41388-024-03172-4. Epub 2024 Sep 28. PMID: 39341991.
- [Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective.](https://pubmed.ncbi.nlm.nih.gov/37269418/) — Ortiz MMO, Andrechek ER. J Mammary Gland Biol Neoplasia. 2023 Jun 3;28(1):12. doi: 10.1007/s10911-023-09540-2. PMID: 37269418.
- [Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity.](https://pubmed.ncbi.nlm.nih.gov/37805590/) — Broeker CD, Ortiz MMO, Murillo MS, Andrechek ER. Breast Cancer Res. 2023 Oct 7;25(1):120. doi: 10.1186/s13058-023-01723-3. PMID: 37805590.
- [Metastasis is altered through multiple processes regulated by the E2F1 transcription factor.](https://pubmed.ncbi.nlm.nih.gov/33947907/) — Swiatnicki MR, Andrechek ER. Sci Rep. 2021 May 4;11(1):9502. doi: 10.1038/s41598-021-88924-y. PMID: 33947907. Free PMC article.
- [Low E2F2 activity is associated with high genomic instability and PARPi resistance.](https://pubmed.ncbi.nlm.nih.gov/33087787/) — Rennhack JP, Andrechek ER. Sci Rep. 2020 Oct 21;10(1):17948. doi: 10.1038/s41598-020-74877-1. PMID: 33087787. Free PMC article.
- [Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives.](https://pubmed.ncbi.nlm.nih.gov/33034778/) — To B, Isaac D, Andrechek ER. J Mammary Gland Biol Neoplasia. 2020 Sep;25(3):191-203. doi: 10.1007/s10911-020-09460-5. Epub 2020 Oct 9. PMID: 33034778. Review.
- [Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data.](https://www.nature.com/articles/s41467-019-10148-6) — Ke Liu, Patrick A. Newbury, Benjamin S. Glicksberg, William Z. D. Zeng, Shreya Paithankar, Eran R. Andrechek, Bin Chen. Nature Communications. 2019.
- [How to Choose a Mouse Model of Breast Cancer, a Genomic Perspective.](https://pubmed.ncbi.nlm.nih.gov/31227983/) — Swiatnicki MR, Andrechek ER. J Mammary Gland Biol Neoplasia. 2019 Sep;24(3):231-243. doi: 10.1007/s10911-019-09433-3. Epub 2019 Jun 21. PMID: 31227983. Review.
- [E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.](https://pubmed.ncbi.nlm.nih.gov/31341204/) — Hollern DP, Swiatnicki MR, Rennhack JP, Misek SA, Matson BC, McAuliff A, Gallo KA, Caron KM, Andrechek ER. Sci Rep. 2019 Jul 24;9(1):10718. doi: 10.1038/s41598-019-47218-0. PMID: 31341204. Free PMC article.
- [Integrated analyses of murine breast cancer models reveal critical parallels with human disease.](https://pubmed.ncbi.nlm.nih.gov/31332182/) — Rennhack JP, To B, Swiatnicki M, Dulak C, Ogrodzinski MP, Zhang Y, Li C, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jayatissa M, Lunt SY, Hunter K, Andrechek ER. Nat Commun. 2019 Jul 22;10(1):3261. doi: 10.1038/s41467-019-11236-3. PMID: 31332182. Free PMC article.
- [Using gene expression data to direct breast cancer therapy: evidence from a preclinical trial.](https://pubmed.ncbi.nlm.nih.gov/29313063/) — Reaz S, Tamkus D, Andrechek ER. J Mol Med (Berl). 2018 Feb;96(2):111-117. doi: 10.1007/s00109-017-1620-7. Epub 2018 Jan 8. PMID: 29313063.
- [Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers.](https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007135) — Daniel P. Hollern, Matthew R. Swiatnicki, Eran R. Andrechek. PLoS Genetics. 2018.
- [Transcription factor compensation during mammary gland development in E2F knockout mice.](https://pubmed.ncbi.nlm.nih.gov/29617434/) — To B, Andrechek ER. PLoS One. 2018 Apr 4;13(4):e0194937. doi: 10.1371/journal.pone.0194937. PMID: 29617434.
- [Effective personalized therapy for breast cancer based on predictions of cell signaling pathway activation from gene expression analysis.](https://www.nature.com/articles/onc2016503) — Jhan JR, Andrechek ER. Oncogene. 2017.
- [Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer.](https://pubmed.ncbi.nlm.nih.gov/28124185/) — Rennhack J, To B, Wermuth H, Andrechek ER. J Mammary Gland Biol Neoplasia. 2017 Mar;22(1):71-84. doi: 10.1007/s10911-017-9374-y. Epub 2017 Jan 26. PMID: 28124185.
- [Triple-negative breast cancer and the potential for targeted therapy.](https://pubmed.ncbi.nlm.nih.gov/29095114/) — Jhan JR, Andrechek ER. Pharmacogenomics. 2017 Nov;18(17):1595-1609. doi: 10.2217/pgs-2017-0117. Epub 2017 Nov 2. PMID: 29095114.
- [Stat3 accelerates Myc induced tumor formation while reducing growth rate in a mouse model of breast cancer.](https://pubmed.ncbi.nlm.nih.gov/27589562/) — Jhan JR, Andrechek ER. Oncotarget. 2016 Oct 4;7(40):65797-65807. doi: 10.18632/oncotarget.11667. PMID: 27589562.
- [Increased metastasis with loss of E2F2 in Myc-driven tumors.](https://pubmed.ncbi.nlm.nih.gov/26474282/) — Yuwanita I, Barnes D, Monterey MD, O'Reilly S, Andrechek ER. Oncotarget. 2015 Nov 10;6(35):38210-38224. doi: 10.18632/oncotarget.5690. PMID: 26474282.
- [HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors.](https://pubmed.ncbi.nlm.nih.gov/24362522/) — Andrechek ER. Oncogene. 2015 Jan 8;34(2):217-225. doi: 10.1038/onc.2013.540. Epub 2013 Dec 23. PMID: 24362522.
- [Conserved E2F mediated metastasis in mouse models of breast cancer and HER2 positive patients.](https://pubmed.ncbi.nlm.nih.gov/26682278/) — Rennhack J, Andrechek E. Oncoscience. 2015;2(10):867-871. doi: 10.18632/oncoscience.259. PMID: 26682278.
- [A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer.](https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3672) — Daniel P. Hollern, Eran R. Andrechek. Breast Cancer Research. 2014.
- [Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.](https://pubmed.ncbi.nlm.nih.gov/25482511/) — Sophia Y. Lunt, Vinayak Muralidhar, Aaron M. Hosios, William J. Israelsen, Dan Y. Gui, Lauren Newhouse, Martin Ogrodzinski, Vivian Hecht, Kali Xu, Paula N. Marín Acevedo, Daniel P. Hollern, Gary Bellinger, Talya L. Dayton, Stefan Christen, Ilaria Elia, Anh T. Dinh, Gregory Stephanopoulos, Scott R. Manalis, Michael B. Yaffe, Eran R. Andrechek, Sarah-Maria Fendt, Matthew G. Vander Heiden. Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4. PMID: 25482511.
- [The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer.](https://pubmed.ncbi.nlm.nih.gov/24934442/) — Hollern DP, Honeysett J, Cardiff RD, Andrechek ER. Mol Cell Biol. 2014 Sep;34(17):3229-3243. doi: 10.1128/MCB.00737-14. Epub 2014 Jun 16. PMID: 24934442.

Full list: https://www.ncbi.nlm.nih.gov/pubmed/?term=andrechek