Metastasis is altered through multiple processes regulated by the E2F1 transcription factor.

Swiatnicki MR, Andrechek ER

Sci Rep. 2021 May 4;11(1):9502. doi: 10.1038/s41598-021-88924-y. PMID: 33947907 Free PMC article.

Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives.

To B, Isaac D, Andrechek ER

J Mammary Gland Biol Neoplasia. 2020 Sep;25(3):191-203. doi: 10.1007/s10911-020-09460-5. Epub 2020 Oct 9. PMID: 33034778 Review.

Low E2F2 activity is associated with high genomic instability and PARPi resistance.

Rennhack JP, Andrechek ER

Sci Rep. 2020 Oct 21;10(1):17948. doi: 10.1038/s41598-020-74877-1. PMID: 33087787 Free PMC article.

Integrated analyses of murine breast cancer models reveal critical parallels with human disease.

Rennhack JP, To B, Swiatnicki M, Dulak C, Ogrodzinski MP, Zhang Y, Li C, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jayatissa M, Lunt SY, Hunter K, Andrechek ER

Nat Commun. 2019 Jul 22;10(1):3261. doi: 10.1038/s41467-019-11236-3. PMID: 31332182 Free PMC article.

E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.

Hollern DP, Swiatnicki MR, Rennhack JP, Misek SA, Matson BC, McAuliff A, Gallo KA, Caron KM, Andrechek ER

Sci Rep. 2019 Jul 24;9(1):10718. doi: 10.1038/s41598-019-47218-0. PMID: 31341204 Free PMC article.

How to Choose a Mouse Model of Breast Cancer, a Genomic Perspective.

Swiatnicki MR, Andrechek ER

J Mammary Gland Biol Neoplasia. 2019 Sep;24(3):231-243. doi: 10.1007/s10911-019-09433-3. Epub 2019 Jun 21. PMID: 31227983 Review.

Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data

Ke Liu, Patrick A. Newbury, Benjamin S. Glicksberg, William Z. D. Zeng, Shreya Paithankar, Eran R. Andrechek & Bin Chen

Nature Communications. 2019

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers

Daniel P. Hollern, Matthew R. Swiatnicki, Eran R. Andrechek

PLoS Genetics. 2018

Effective personalized therapy for breast cancer based on predictions of cell signaling pathway activation from gene expression analysis

Jhan JR and Andrechek ER.

Oncogene. 2017

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

Sophia Y. Lunt, Vinayak Muralidhar, Aaron M. Hosios, William J. Israelsen, Dan Y. Gui, Lauren Newhouse, Martin Ogrodzinski, Vivian Hecht, Kali Xu, Paula N. Marín Acevedo, Daniel P. Hollern, Gary Bellinger, Talya L. Dayton, Stefan Christen, Ilaria Elia, Anh T. Dinh, Gregory Stephanopoulos, Scott R. Manalis, Michael B. Yaffe, Eran R. Andrechek, Sarah-Maria Fendt, Matthew G. Vander Heiden

Molecular Cell. 2014

A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer

Daniel P Hollern and Eran R Andrechek

Breast Cancer Research. 2014

Link to Pubmed for Andrechek lab papers