Eran Andrechek
Eran Andrechek, PhD
Professor
Department of Physiology
Michigan State University
[email protected]
Eran Andrechek received his B.Sc. and Ph.D. from McMaster University in Ontario. His dissertation research characterized the role of HER2 in both normal development and in breast cancer using innovative new genetically engineered models under the training of Dr. William Muller. For postdoctoral work, Dr. Andrechek joined the lab of Dr. Joseph Nevins at Duke University where he integrated bioinformatic analysis with mouse models of breast cancer.
Since starting his laboratory at Michigan State, Dr. Andrechek has focused on the integration of genomics with mouse models of breast cancer. This has included the generation of new models as well as use of CRISPR/Cas9 systems to rapidly test bioinformatically generated hypotheses in human breast cancer cell lines. Each student in the lab is trained in both computational work and traditional “wet work” in an interdisciplinary approach.
Research in the laboratory has been supported by the NIH / NCI, DoD, Pardee Foundation, AICR, Metavivor, Aitch Foundation and Susan G. Komen. This has resulted in numerous publications since starting the laboratory in 2009 in journals including Molecular Cell, PLoS Genetics, Cancer Research, Oncogene and many others. A full list of manuscripts is available under the Publications tab above.

Current Trainees

Carson Broeker

Carson Broeker
Carson is working on a DoD funded project on an amplification event in HER2+ breast cancer, distinct from the HER2 amplification. This event is associated with higher rates of metastasis and alterations to the tumor microenvironment. He is using CRISPR and computational tools to functionally characterize the genes in the secondary amplification event and their roles in metastasis.
More...

Mylena Ortiz

Mylena Ortiz
Mylena's project is to examine how mutations in a protein tyrosine phosphatase regulate signaling pathways and how this impacts tumor biology. After initial mutational work this will result in research into personalized therapy.
More...

John Vusich

John Vusich
John is examining the transcriptional regulation impacted by repressor transcription factors in the mammary gland. This includes determination of specific targets and how the targets are distinct from activator transcription factors in the same family. He is also using bulk and scRNAseq to examine both mammary gland development and tumor biology.
More...

Jesus Garcia-Lerena

Jesus Garcia-Lerena
Jesus has a project where he is examing altered mammary development and metastatic tumor biology in a new line of genetically engineered mice that we have developed. A specific focus is on the development of lymphatic metastasis and the genetic programs that regulate the migration to specific distant sites.
More...

Anthony Schulte

Anthony Schulte
Anthony is working on a project looking at the impact of spontaneous mutations in genes that alter the tumor biology of genetically engineered tumors in mouse models. Initial focus is on cKit and RARa.
More...

Caroline Downes

Caroline Downes
Caroline is doing a senior undergraduate thesis project following up on the impact of several mutations noted in the MMTV-Myc transgenic model.
More...

Alumni

Lab Alumni Group Photo

Daniel Hollern - Assistant Professor Salk Institute

Inez Yuwanita - Lecturer San Jose State University

Sophia Lunt - Associate Professor, MSU

Jing-Ru Jhan - Crown Biosciences

Jon Rennhack - Postdoc, Bill Hahn Lab

Jordan Honeysett - Pharmacist

Matt Swiatnicki - Promega

Briana To - PGY1, tOSU

Eran Andrechek
Eran Andrechek, PhD
[email protected]
Professor | Department of Physiology | Michigan State University
 
Eran Andrechek received his B.Sc. and Ph.D. from McMaster University in Ontario. His dissertation research characterized the role of HER2 in both normal development and in breast cancer using innovative new genetically engineered models under the training of Dr. William Muller. For postdoctoral work, Dr. Andrechek joined the lab of Dr. Joseph Nevins at Duke University where he integrated bioinformatic analysis with mouse models of breast cancer.
Since starting his laboratory at Michigan State, Dr. Andrechek has focused on the integration of genomics with mouse models of breast cancer. This has included the generation of new models as well as use of CRISPR/Cas9 systems to rapidly test bioinformatically generated hypotheses in human breast cancer cell lines. Each student in the lab is trained in both computational work and traditional “wet work” in an interdisciplinary approach.
Research in the laboratory has been supported by the NIH / NCI, DoD, Pardee Foundation, AICR, Metavivor, Aitch Foundation and Susan G. Komen. This has resulted in numerous publications since starting the laboratory in 2009 in journals including Molecular Cell, PLoS Genetics, Cancer Research, Oncogene and many others. A full list of manuscripts is available under the Publications tab above.

Current Trainees

Carson Broeker

Carson Broeker
Carson is working on a DoD funded project on an amplification event in HER2+ breast cancer, distinct from the HER2 amplification. This event is associated with higher rates of metastasis and alterations to the tumor microenvironment. He is using CRISPR and computational tools to functionally characterize the genes in the secondary amplification event and their roles in metastasis.

Mylena Ortiz

Mylena Ortiz
Mylena's project is to examine how mutations in a protein tyrosine phosphatase regulate signaling pathways and how this impacts tumor biology. After initial mutational work this will result in research into personalized therapy.

John Vusich

John Vusich
John is examining the transcriptional regulation impacted by repressor transcription factors in the mammary gland. This includes determination of specific targets and how the targets are distinct from activator transcription factors in the same family. He is also using bulk and scRNAseq to examine both mammary gland development and tumor biology.

Jesus Garcia-Lerena

Jesus Garcia-Lerena
Jesus has a project where he is examing altered mammary development and metastatic tumor biology in a new line of genetically engineered mice that we have developed. A specific focus is on the development of lymphatic metastasis and the genetic programs that regulate the migration to specific distant sites.

Anthony Schulte

Anthony Schulte
Anthony is working on a project looking at the impact of spontaneous mutations in genes that alter the tumor biology of genetically engineered tumors in mouse models. Initial focus is on cKit and RARa.

Caroline Downes

Caroline Downes
Caroline is doing a senior undergraduate thesis project following up on the impact of several mutations noted in the MMTV-Myc transgenic model.


Alumni

Lab Alumni Group Photo

Daniel Hollern - Assistant Professor Salk Institute

Inez Yuwanita - Lecturer San Jose State University

Sophia Lunt - Associate Professor, MSU

Jing-Ru Jhan - Crown Biosciences

Jon Rennhack - Postdoc, Bill Hahn Lab

Jordan Honeysett - Pharmacist

Matt Swiatnicki - Promega

Briana To - PGY1, tOSU