Eran Andrechek
Eran Andrechek, PhD
Associate Professor
Department of Physiology
Michigan State University
andrech1@msu.edu
Eran Andrechek received his B.Sc. and Ph.D. from McMaster University in Ontario. His dissertation research characterized the role of HER2 in both normal development and in breast cancer using innovative new genetically engineered models under the training of Dr. William Muller. For postdoctoral work, Dr. Andrechek joined the lab of Dr. Joseph Nevins at Duke University where he integrated bioinformatic analysis with mouse models of breast cancer.
Since starting his laboratory at Michigan State, Dr. Andrechek has focused on the integration of genomics with mouse models of breast cancer. This has included the generation of new models as well as use of CRISPR/Cas9 systems to rapidly test bioinformatically generated hypotheses in human breast cancer cell lines. Each student in the lab is trained in both computational work and traditional “wet work” in an interdisciplinary approach.
Research in the laboratory has been supported by the NIH / NCI, DoD, Pardee Foundation, AICR, Metavivor, Aitch Foundation and Susan G. Komen. This has resulted in 22 publications since starting the laboratory in 2009 in journals including Molecular Cell, PLoS Genetics, Cancer Research, Oncogene and many others. A full list of manuscripts is available under the Publications tab above.

Current Trainees

Briana To

Briana To @Briana_To_
New model of lymphatic metastasis in breast cancer Briana is a dual degree DO / PhD student and her research is focused on the characterization of a new pre-clinical model of breast cancer. This model is unique in that it progresses to lymphatic metastases, mirroring human breast cancer. She is investigating the model using a combination of molecular, gene expression, sequencing and transplantation approaches. Briana’s other work in the lab includes a paper examining transcription factor compensation during mammary gland development.
More...

Matt Swiatnicki

Matt Swiatnicki
Regulation of phosphorylation in cancer Matt is a PhD student in the lab and his primary project is examining the impact of mutations we have uncovered after sequencing the tumor genome of MMTV-PyMT tumors. Matt is focused on a phosphatase that normally regulates EGFR and is examining the impact of mutations through a combination of drug screening and CRISPR directed mutagenesis. Matt’s other work includes a review of mouse models of breast cancer and a project examining impact of E2Fs on metastasis and genomic mutations.
More...

Alumni

​JingRu Jhan

Daniel Hollern

​Inez Yuwanita

Jordan Honeysett

Eran Andrechek
Eran Andrechek, PhD
andrech1@msu.edu
Associate Professor | Department of Physiology | Michigan State University
 
Eran Andrechek received his B.Sc. and Ph.D. from McMaster University in Ontario. His dissertation research characterized the role of HER2 in both normal development and in breast cancer using innovative new genetically engineered models under the training of Dr. William Muller. For postdoctoral work, Dr. Andrechek joined the lab of Dr. Joseph Nevins at Duke University where he integrated bioinformatic analysis with mouse models of breast cancer.
Since starting his laboratory at Michigan State, Dr. Andrechek has focused on the integration of genomics with mouse models of breast cancer. This has included the generation of new models as well as use of CRISPR/Cas9 systems to rapidly test bioinformatically generated hypotheses in human breast cancer cell lines. Each student in the lab is trained in both computational work and traditional “wet work” in an interdisciplinary approach.
Research in the laboratory has been supported by the NIH / NCI, DoD, Pardee Foundation, AICR, Metavivor, Aitch Foundation and Susan G. Komen. This has resulted in 22 publications since starting the laboratory in 2009 in journals including Molecular Cell, PLoS Genetics, Cancer Research, Oncogene and many others. A full list of manuscripts is available under the Publications tab above.

Current Trainees


Briana To

Briana To @Briana_To_
New model of lymphatic metastasis in breast cancer Briana is a dual degree DO / PhD student and her research is focused on the characterization of a new pre-clinical model of breast cancer. This model is unique in that it progresses to lymphatic metastases, mirroring human breast cancer. She is investigating the model using a combination of molecular, gene expression, sequencing and transplantation approaches. Briana’s other work in the lab includes a paper examining transcription factor compensation during mammary gland development.
More...

Matt Swiatnicki

Matt Swiatnicki
Regulation of phosphorylation in cancer Matt is a PhD student in the lab and his primary project is examining the impact of mutations we have uncovered after sequencing the tumor genome of MMTV-PyMT tumors. Matt is focused on a phosphatase that normally regulates EGFR and is examining the impact of mutations through a combination of drug screening and CRISPR directed mutagenesis. Matt’s other work includes a review of mouse models of breast cancer and a project examining impact of E2Fs on metastasis and genomic mutations.
More...


Alumni


​JingRu Jhan

Daniel Hollern

​Inez Yuwanita

Jordan Honeysett